My research focuses upon the brain's ability to select sounds of interest out of noise. Signal extraction appears to rely upon auditory pathways that descend from higher brain centers to the brainstem and the ear. We use a combination of intracellular anatomical and physiological approaches to examine relationships between discrete ascending and descending auditory pathways. The lab's principal research tool is a slice preparation of the mammalian auditory brainstem. This preparation is used to generate data for subsequent microscopic, immunocytochemical, and ultrastructural analysis. < P>Representative publications:
Kuwabara, N., M.A. Notestine, and J.M. Zook (1995) Descending projections from the inferior colliculus to the ventral nucleus of the trapezoid body. Soc. Neurosci. Abs. 21:674
Zook, J.M., B.L. Schanbacher, N. Kuwabara, and M. Notestine (1995) The dorsal nucleus of the lateral lemniscus sends dendritic arbors to the lateral brainstem surface. Soc. Neurosci. Abs. 21:674.
Ogle, B.B., B.L. Holtzmeier, M.A. Notestine, and J.M. Zook (1994) A new model for studying the developing brain. J. Am. Ost. Ass. 49:762
Kuwabara, N. and J.M. Zook (1994) The relation between afferent and efferent axons in the superior paraolivary nucleus of the gerbil. Assoc. Res. Otolaryn. 17:24.
Casseday, J.H., J.M. Zook and N. Kuwabara (1993) Projections of cochlear nucleus to superior olivary complex in an echolocating bat: Relation to function. In: The Mammalian Cochlear Nuclei: Organization and Function. Merchan, M.A., J.M. Juiz and D.A. Godfrey , eds. Plenum, New York.
Casseday, J.H., J.M. Zook and N. Kuwabara (1993) Superior olivary cells with descending projections to the cochlear nucleus. In: The Mammalian Cochlear Nuclei: Organization and Function. Merchan, M.A., J.M. Juiz, and D.A. Godfrey, eds. Plenum, New York.
Kuwabara, N. and J.M. Zook (1993) Transport of extracellularly injected biocytin and neurobiotin in superior olivary tissue slices. Soc. Neurosci. Abs. 19:1204.
Tuck, G.P., N. Kuwabara, and J.M. Zook ( 1993) Neurons with intrinsic axonal terminations in the gerbil's lateral lemniscus. Soc. Neurosci. Abs. 19:1204.
Zook, J.M. and N. Kuwabara (1992) Projections to the medial superior olive from the medial and lateral nuclei of the trapezoid body in rodents and bats. J. Comp. Neurol. 325:117.
Kuwabara, N., R.A. DiCaprio, and J.M. Zook (1991) Afferents to the medial nucleus of the trapezoid body and their collateral projections. J. Comp. Neurol. 314:684-706.
Kuwabara, N. and J.M. Zook (1991) Classification of the principal cells of the medial nucleus of the trapezoid body. J. Comp. Neurol. 314:707-720.
Zook, J.M. and R.A. DiCaprio (1990) A potential system of delay lines in the dolphin auditory brainstem. In: Sensory Abilities of Cetaceans: Laboratory and Field Evidence. Thomas, J. and R. Kastelein, eds., Plenum, New York, pp. 181-193.
Zook, J.M. and P.A. Leake (1989) Connections and frequency representation in the auditory brainstem of the mustache bat, Pt eronotus parnellii. J. Comp. Neurol. 290:243-261.
Zook, J.M. and R.A. DiCaprio (1988) Intracellular labeling of afferents to the lateral superior olive in the bat, Eptesicus fuscus. Hearing Research 34:141-148.
Zook, J.M., M.S. Jacobs, I. Glezer, and P.J. Morgane (1988) Some comparative aspects of auditory brainstem cytoarchitecture in echolocating mammals: Speculations on the morphological basis of time-domain signal processing. In: Animal Sonar: Processes and Performance I>, Nachtigall, P.E. and P.W.B. Moore, eds., Plenum, New York, pp. 311-316.