The Na+/Ca2+ exchanger is important in maintaining low intracellular Ca2+ concentration in neurons. Normally the exchanger is thought to provide the principle efflux pathway for Ca2+. However, the exchanger is reversible and under certain conditions (e.g., depolarization) can contribute to Ca2+ influx.
Simplified model of zinc plasma membrane transport in a hippocampal neuron that sequesters zinc in synaptic vesicles.
Back to main page